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WebA systematic search was conducted on PubMed, EMBASE, Web of Sciences, Scopus, and the Cochrane Library databases. A meta-analysis was conducted to determine any associations between genetic polymorphisms and pharmacokinetic or pharmacodynamic parameters of MPA. Pooled-effect estimates were calculated by means of the random-effects model. Weband the time dependency of the pharmacodynamics of the tested drug [3,16]. Relatively simple PK–PD models are needed to describe PK–PD relationships after multiple doses or long-term infusion, because the system is kinetically at steady state [16]. The most common mathematical equations employed in steady-state conditions are the linear ... WebDec 7, 2024 · Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured ... Data represent means ± SD (n = 3); *P < 0.05 and **P < 0.01 versus the controls ... Permission is granted subject to the terms of the License under which the work was ... fnb fee schedule pa