Hepatocellularity翻译

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WebAims: To determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of human liver and their interindividual variability. Methods: Triplicate liver … WebReported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of liver, generally with no consideration of the extent of their inter-individual variability. We have collated and analysed data from a number of …

Determination of microsome and hepatocyte scaling factors for

Web1 dec. 2006 · Biotransformation rates measured using cryopreserved trout hepatocytes can be extrapolated to the whole animal to predict metabolism impacts on chemical bioaccumulation, and hepatocytes from male and female juvenile trout may be used interchangeably for in vitro–in vivo metabolism extrapolations. Expand 25 Highly Influenced WebMean(geo) hepatocellularity was 163 x 10(6) cells g(-1) liver for Wistar rats (95% CI = 127-199 x 10(6) cells g(-1) liver) and 169 x 10(6) cells g(-1) liver (95% CI = 131-207 x 10(6) … snowboard female

The effects of aging on hepatic microsomal scaling factor and ...

WebApproximately 60% of marketed compounds are cleared by hepatic CYP-mediated metabolism 1. Hepatocytes contain the full complement of hepatic drug metabolizing … Web28 jan. 2010 · Sandwich-cultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to study hepatobiliary drug transport, species differences in drug transport, transport protein regulation, drug-drug interactions, and hepatotoxicity. WebNoun [ edit] hepatocellularity ( uncountable ) The condition of being hepatocellular. This page was last edited on 11 March 2024, at 09:48. Text is available under the Creative … roasting masters chocolate

Inter-individual variability in levels of human microsomal protein …

HEPATOCELLULAR在剑桥英语词典中的解释及翻译

WebScaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and … Web1 aug. 1997 · Microsomal protein recovery and hepatocellularity have been determined and investigated as scaling factors for interrelating clearance by hepatic microsomes, freshly isolated hepatocytes and whole liver from untreated (UT) rats and rats treated with either the cytochrome P450 inducer phenobarbital (PB) or dexamethasone (DEX). snowboard femininoWeb1 feb. 2014 · Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro (2006) L.T. Lee et al. Removal of unbound sodium dodecyl sulfate (SDS) from proteins in solution by electrophoresis through triton X-100-agarose. snowboard finance

"Webhepatocellularity (3.1×109 cells per kilogram body weight, dotted line in Fig. 1)(27). Similar regression analyses for different datasets found that the empirical scaling factors necessary for accurate predictions were 5.2-fold (35) and 5.6-fold larger (45) than hepatocellularity (2.5–3.1×109 cells per " - Hepatocellularity翻译

Hepatocellularity翻译

WebThe present work profiles the hepatocellularity number in male Wistar rats as a function of age. Using the NADPH–cytochrome P450 reductase (NCR) activity method, the mean HPGL for the adult rat (8 weeks) was 104 × 106 cells/gram liver … Web1 dec. 2006 · Hepatocellularity numbers were calculated from the ratio between the liver protein concentration and the protein concentration in the corresponding hepatocyte …

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Web34 Current Drug Metabolism, 2007, Vol. 8, No. 1 Barter et al. weight to give an estimate of whole organ intrinsic clear-ance. The scaling factors for data from liver microsomes, hepatocytes ... WebFor instance, when hepatocytes are used to predict hepatic drug clearance, the hepatocellularity (number of hepatocytes per gram liver, HPGL) is required as one of …

WebAims: To determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of human liver and their interindividual variability. Methods: Triplicate liver samples were used to determine values of MPPGL (n = 20) and HPGL (n = 7) after accounting for the fractional loss of microsomal protein or hepatocytes during processing. WebHepatocytes / physiology* Male NADPH-Ferrihemoprotein Reductase / metabolism Pharmaceutical Preparations / metabolism* Rats Rats, Wistar

WebMean geo hepatocellularity was 163 × 10 6 cells g −1 liver for Wistar rats (95% CI = 127–199 × 10 6 cells g −1 liver) and 169 × 10 6 cells g −1 liver (95% CI = 131–207 × 10 6 cells g −1 liver) for beagle dogs. The data generated in this study indicate a consistency in scaling factors between rat and dog. Web28 jul. 2016 · The hepatocellularity of the Göttingen minipig was assessed based on the DNA and the protein quantification methods previously used for other species (53,58). For both methodologies, specific amounts of hepatocytes suspension cultures were compared to a specific amount of homogenized liver tissue, assuming that the liver tissue is mainly …

Webhepatocellular 音标：/ˌhepətəu'seljulə/ 全球发音：生词本：添加笔记：有奖纠错划词英汉-汉英词典词组搭配英语例句库全文检索英汉-汉英词典 adj. 细胞的词组习惯用语 …

Web12 sep. 2003 · Bayliss commented recently on hepatocellularity values, emphasizing the uncertainty of interspecies scaling and indicating that appropriate scaling factors remain to be clarified. Therefore, although the value of 120 × 10 6 cells per gram of liver has often been used in human IVIVE [ 18, 19 ], its accuracy in relation to interindividual differences … roasting meaningWebReported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and … snowboard female 2017Web1 dec. 2006 · Hepatocellularity numbers were calculated from the ratio between the liver protein concentration and the protein concentration in the corresponding hepatocyte … snowboard findenWeb美 [haɪpəseljʊ'lærɪtɪ] 是什么意思释义 [医]细胞过多；英英释义 hypercellularity n.the state of having abnormally many cells 学习怎么用权威例句 hypercellularity hypercellularity Does … snowboard fahren hamburgWeb7 mrt. 2024 · To accurately predict human clearance, it is essential to understand the clearance mechanisms involved (i.e., hepatic metabolism, hepatic uptake, biliary secretion, or renal clearance), so that appropriate methods can be applied to the predictions. snowboard filme 2015Web英 [hepətəʊ'seljʊlə] 美 [hepətoʊ'seljʊlə] 是什么意思 adj. 肝细胞的；学习怎么用词组短语 hepatocellular carcinoma 肝细胞癌；肝细胞性肝癌权威例句 Mutational hot spot in the … roasting minced garlicWeb1. Scaling factor values for the in vitro-in vivo extrapolation of hepatic metabolic clearance for xenobiotics have not yet been determined in horses. Scaling factors were determined … roasting mickey mouse