WebApr 26, 2024 · Thirteen cases had intact serosa, and the remaining 22 perforated the serosa, including 7 with peritoneal acellular mucin beyond appendiceal serosa and 10 with grade 2 pseudomyxoma peritonei. ... with columnar cells that have eosinophilic cytoplasm and lack apical cytoplasmic mucin, although most cases had at least some areas in … WebPASd may show granular cytoplasmic mucin stain; Indistinct cell borders; Uniform, low grade small nuclei. Small nucleoli; Mitotic count generally 1-2/10 hpf; Intracytoplasmic lumens rare to frequent Highlighted by Alcian Blue or EMA stains; May result in areas with signet ring appearance;
Mucins in cancer: function, prognosis and therapy
WebAug 19, 2016 · A periodic acid-Schiff stain demonstrates diffuse cytoplasmic mucin, with apparent basal sparing because of the nuclei. FIGURE 76.3 Mucinous adenocarcinoma in situ, goblet cell … easton armstrong scouting report
A retrospective study on incidence, diagnosis ... - Diagnostic …
WebThe inclusions were divided into 3 groups: serous epithelial lined with typical ciliated morphology but with distinct basophilic cytoplasmic mucin in some or all of the lining … WebAug 16, 2024 · Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic intraductal neoplasm. It is characterized by a tubulopapillary growth pattern, entirely high-grade atypical cells, minimal cytoplasmic mucin, and no obvious luminal mucin secretion. Most of its biological nature remains unclear. We herein report a case of intrapancreatic recurrence … Mucins are secreted as massive aggregates of proteins with molecular masses of roughly 1 to 10 million Da. Within these aggregates, monomers are linked to one another mostly by non- covalent interactions, although intermolecular disulfide bonds may also play a role in this process. Secretion [ edit] See more Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a … See more Human mucins include genes with the HUGO symbol MUC 1 through 22. Of these mucins, the following classes have been defined by … See more The functional classification does not correspond to an exact evolutionary relationship, which is still incomplete and ongoing. Known-related groups include: • The … See more Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes … See more Mature mammalian mucins are composed of two distinct regions: • The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. … See more Mucins have been found to have important functions in defense against bacterial and fungal infections. MUC5B, the predominant mucin in the mouth and female genital tract, … See more Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. Fusion of the vesicles to the plasma membrane causes release of the mucin, which as … See more easton animal shelter easton pa