Bone vascular niche e-selectin
WebOct 1, 2005 · The bone marrow vascular niche comprises diverse vascular structures Immunohistochemical staining of a paraffin bone marrow section with antiMECA-32 (panendothelial antigen) antibody demonstrates the diversity of the bone marrow’s vasculature. Note the elongated arterioles (arrow) and the sinusoidal vessels (arrowheads). WebApr 14, 2014 · The idea that sinusoids may represent a proliferative niche is consistent with recent studies indicating that E-selectin, an adhesion molecule constitutively expressed in certain bone marrow sinusoidal microdomains, promotes HSCs proliferation and blockade of E-selectin protects HSCs following chemotherapy or γ -irradiation [ 37, 38 ].
Bone vascular niche e-selectin
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WebDec 7, 2024 · The vascular adhesion molecule E-selectin is a key component of the bone marrow (BM) vascular niche, awakening otherwise dormant hematopoietic stem cells (HSC) (Winkler et al., Nat Med 2012). Vascular niches also mediate malignant cell survival. WebTwo anatomical niches for hematopoietic stem cells (HSCs) have been reported in the …
WebMar 13, 2024 · Here, we provide evidence suggesting the possible involvement of RUNX transcription factors in the transactivation of E-selectin, a member of selectin family of cell adhesion molecules, on the vascular endothelial cells of the mice bone marrow niche. WebJun 16, 2005 · ICAM-1, VCAM-1 and P-selectin are expressed throughout the bone marrow vasculature. Arrows in c indicate P-selectin-positive megakaryocytes. e, f, Montage images of extended PECAM-1...
WebApr 27, 2024 · The endothelial cell adhesion molecule E-selectin is a key component of the bone marrow hematopoietic stem cell (HSC) vascular niche regulating balance between HSC self-renewal and commitment. We now report in contrast, E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. WebNov 29, 2024 · The endosteal bone marrow niche is known to protect leukemic stem cells (LSC) from chemotherapy, but the role of the vascular niche in the bone marrow microenvironment in leukemia is largely unknown. E-selectin, which is expressed on bone marrow endothelial cells, has been described to regulate the dormancy of normal …
WebE-selectin, an adhesion molecule exclusively expressed on endothelial cells and …
WebE-selectin, an adhesion molecule exclusively expressed on endothelial cells and activated by cytokines, is an essential component of the vascular niche in the BM microenvironment, where it promotes the proliferation of … hosted by atlasWebVascular niche E-selectin regulates hematopoietic stem cell dormancy, self … psychology in depthpsychology in designWebScientist with a background in biochemistry and experience in basic/translational immuno-oncology research. My skill set includes cell and molecular biology techniques, in vivo mouse work, and clinical study. In my research, I have lead small groups on team projects and collaborated with a multi-disciplinary team of scientists and clinicians. I am able to … psychology in dlsuWebMay 1, 2024 · Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis Authors: Mark Esposito Princeton University … psychology in dsmpWebBone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt … psychology in des moines iowaWebDec 24, 2024 · Winkler et al.[ 41] showed that an increase of E-selectin at the vascular HSC niche in the bone marrow corresponds to a stimulation of proliferation and differentiation of dormant HSCs: following antileukemic chemotherapy or radiation treatment, E-selectin expression increases at the level of bone marrow by about 10-20-fold during … hosted by best-lucky-cat.xyz